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leiomyosarcoma ulms cell line  (ATCC)


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    ATCC leiomyosarcoma ulms cell line
    Leiomyosarcoma Ulms Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 146 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/leiomyosarcoma+ulms+cell+line/us12377103-94-58-63?v=ATCC
    Average 95 stars, based on 146 article reviews
    leiomyosarcoma ulms cell line - by Bioz Stars, 2026-07
    95/100 stars

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    leiomyosarcoma ulms cell line  (ATCC)
    95
    ATCC leiomyosarcoma ulms cell line
    Leiomyosarcoma Ulms Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/leiomyosarcoma+ulms+cell+line/us12377103-94-58-63?v=ATCC
    Average 95 stars, based on 1 article reviews
    leiomyosarcoma ulms cell line - by Bioz Stars, 2026-07
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    uterine leiomyosarcoma ulms cell line  (ATCC)
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    ATCC uterine leiomyosarcoma ulms cell line
    IHC staining of BRD2, 3, and 4 in human <t>uLMS</t> tissues and adjacent myometrium. IHC staining for BRD2, 3, and 4 is presented with two representative cases. The right column shows the density map of BRD2, 3, and 4 for the same representative case. Blue color: negative; yellow color: low expression; brown color: moderate expression; red color: strong expression. MM: myometrial tissues; LMS: <t>leiomyosarcoma.</t>
    Uterine Leiomyosarcoma Ulms Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/leiomyosarcoma+ulms+cell+line/pmc11394028-52-1-7?v=ATCC
    Average 95 stars, based on 1 article reviews
    uterine leiomyosarcoma ulms cell line - by Bioz Stars, 2026-07
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    IHC staining of BRD2, 3, and 4 in human uLMS tissues and adjacent myometrium. IHC staining for BRD2, 3, and 4 is presented with two representative cases. The right column shows the density map of BRD2, 3, and 4 for the same representative case. Blue color: negative; yellow color: low expression; brown color: moderate expression; red color: strong expression. MM: myometrial tissues; LMS: leiomyosarcoma.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: IHC staining of BRD2, 3, and 4 in human uLMS tissues and adjacent myometrium. IHC staining for BRD2, 3, and 4 is presented with two representative cases. The right column shows the density map of BRD2, 3, and 4 for the same representative case. Blue color: negative; yellow color: low expression; brown color: moderate expression; red color: strong expression. MM: myometrial tissues; LMS: leiomyosarcoma.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Immunohistochemistry, Expressing

    Percentage of BET protein-positive cells and H-score of BET protein expression in uLMS vs. myometrium. ( A ) Percentage of BRD2, BRD3, and BRD4 positive cells in uLMS and myometrium tissues. ( B ) H-score of BRD2, BRD3, and BRD4 in uLMS and myometrium tissues. * p < 0.05. *** p < 0.001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: Percentage of BET protein-positive cells and H-score of BET protein expression in uLMS vs. myometrium. ( A ) Percentage of BRD2, BRD3, and BRD4 positive cells in uLMS and myometrium tissues. ( B ) H-score of BRD2, BRD3, and BRD4 in uLMS and myometrium tissues. * p < 0.05. *** p < 0.001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Expressing

    Treatment with JQ1 and I-BET 762 decreases uLMS cell viability and induces cell cycle arrest. ( A ) Cell viability of SK-UT-1 and UTSM cells were measured with trypan blue exclusion assay in the presence or absence of JQ1 and I-BET 762 for 48 h. ( B ) Treatment with JQ1 and I-BET 762 induces cell cycle arrest. Flow cytometric analysis was performed to measure the cell cycle phase distribution in SK-UT-1 uLMS cells in the presence or absence of JQ1 and I-BET 762. Cell cycle phases were marked as purple (G1), olive green (S), and light green (G2). Quantitative cell population analysis in response to JQ1 and I-BET 762 treatment was performed, respectively (right panel). DMSO group ( n = 4), JQ1 ( n = 4), I-BET 762 ( n = 4). ns: no significant difference; * p < 0.05; *** p < 0.001; **** p < 0.0001. ns: no significant difference. n indicates the number of biological samples for each group.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: Treatment with JQ1 and I-BET 762 decreases uLMS cell viability and induces cell cycle arrest. ( A ) Cell viability of SK-UT-1 and UTSM cells were measured with trypan blue exclusion assay in the presence or absence of JQ1 and I-BET 762 for 48 h. ( B ) Treatment with JQ1 and I-BET 762 induces cell cycle arrest. Flow cytometric analysis was performed to measure the cell cycle phase distribution in SK-UT-1 uLMS cells in the presence or absence of JQ1 and I-BET 762. Cell cycle phases were marked as purple (G1), olive green (S), and light green (G2). Quantitative cell population analysis in response to JQ1 and I-BET 762 treatment was performed, respectively (right panel). DMSO group ( n = 4), JQ1 ( n = 4), I-BET 762 ( n = 4). ns: no significant difference; * p < 0.05; *** p < 0.001; **** p < 0.0001. ns: no significant difference. n indicates the number of biological samples for each group.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Trypan Blue Exclusion Assay

    Treatments with JQ1 and I-BET 762 sculpt the transcriptome of uLMS cells. Heat maps are presented to cluster DEGs (JQ1 vs. control) ( A ) and (I-BET 762 vs. control) ( B ), respectively. Volcano plots of gene expression profiles are presented for JQ1 vs. control ( C ) and I-BET 762 vs. control ( D ). The red and blue points represent upregulated and downregulated genes, respectively. The vertical dotted and the horizontal black lines represent the log (FC) cutoff and the logarithmic transformed adjusted p -value cutoff, respectively. ( E ) Upset diagram showing the intersection size of upregulated and downregulated genes across drug treatments. ( F ) Distribution of overlapped DEGs in response to JQ1 and I-BET 762 treatments. FC: fold-change.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: Treatments with JQ1 and I-BET 762 sculpt the transcriptome of uLMS cells. Heat maps are presented to cluster DEGs (JQ1 vs. control) ( A ) and (I-BET 762 vs. control) ( B ), respectively. Volcano plots of gene expression profiles are presented for JQ1 vs. control ( C ) and I-BET 762 vs. control ( D ). The red and blue points represent upregulated and downregulated genes, respectively. The vertical dotted and the horizontal black lines represent the log (FC) cutoff and the logarithmic transformed adjusted p -value cutoff, respectively. ( E ) Upset diagram showing the intersection size of upregulated and downregulated genes across drug treatments. ( F ) Distribution of overlapped DEGs in response to JQ1 and I-BET 762 treatments. FC: fold-change.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Control, Gene Expression, Transformation Assay

    JQ1 and I-BET 762 altered cell cycle- and apoptosis-related gene expression in uLMS cells. RNA-seq analysis revealed the upregulation of CDKN1A and BIK and the downregulation of CDK6 and BCL2 , respectively, in uLMS cells upon BETis treatment. NS: no significant difference; * p < 0.05; *** p < 0.001; **** p < 0.0001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 altered cell cycle- and apoptosis-related gene expression in uLMS cells. RNA-seq analysis revealed the upregulation of CDKN1A and BIK and the downregulation of CDK6 and BCL2 , respectively, in uLMS cells upon BETis treatment. NS: no significant difference; * p < 0.05; *** p < 0.001; **** p < 0.0001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Gene Expression, RNA Sequencing

    JQ1 and I-BET 762 altered the Hedgehog pathway in uLMS cells. Hallmark analysis demonstrated the enrichment of the Hedgehog pathway in SK₋UT₋1 cells in response to JQ1 ( A ) and I-BET 762 ( B ) treatments. The key components of the Hedgehog pathway, including GLI1 ( C ), GLI2 ( D ), GLI3 ( E ), and SMO ( F ), are downregulated in response to JQ1 and I-BET 762 treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001. ns: no significant difference.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 altered the Hedgehog pathway in uLMS cells. Hallmark analysis demonstrated the enrichment of the Hedgehog pathway in SK₋UT₋1 cells in response to JQ1 ( A ) and I-BET 762 ( B ) treatments. The key components of the Hedgehog pathway, including GLI1 ( C ), GLI2 ( D ), GLI3 ( E ), and SMO ( F ), are downregulated in response to JQ1 and I-BET 762 treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001. ns: no significant difference.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques:

    JQ1 and I-BET 762 altered the EMT pathway in uLMS cells. Hallmark analysis demonstrated the enrichment of the EMT pathway in SK₋UT₋1 cells in response to JQ1 ( A ) and I-BET 762 ( B ) treatments. The EMT inducers, including PDGFRβ ( C ), CCND2 ( D ), IL32 ( E ), and TNC ( F ), are downregulated in response to BETi treatment. *** p < 0.001; **** p < 0.0001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 altered the EMT pathway in uLMS cells. Hallmark analysis demonstrated the enrichment of the EMT pathway in SK₋UT₋1 cells in response to JQ1 ( A ) and I-BET 762 ( B ) treatments. The EMT inducers, including PDGFRβ ( C ), CCND2 ( D ), IL32 ( E ), and TNC ( F ), are downregulated in response to BETi treatment. *** p < 0.001; **** p < 0.0001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques:

    Targeted inhibition of BET proteins suppressed the gene expression of TFs, contributing to cancer metastasis and progression. ( A ) The list of DEGs of TFs ( B ) RNA-seq revealed the downregulation of TF genes, including ZNF37A , NFIB , NFATC4 , KLF13 , GTF2I , and ZNF507 in uLMS cells.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: Targeted inhibition of BET proteins suppressed the gene expression of TFs, contributing to cancer metastasis and progression. ( A ) The list of DEGs of TFs ( B ) RNA-seq revealed the downregulation of TF genes, including ZNF37A , NFIB , NFATC4 , KLF13 , GTF2I , and ZNF507 in uLMS cells.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Inhibition, Gene Expression, RNA Sequencing

    JQ1 and I-BET 762 treatments altered DNA methylation-related genes in uLMS cells. RNA−seq revealed the downregulation of DNMT3A , DNMT3B , DNMT1 , TET1 , and TET2 in uLMS cells in response to JQ1 and I-BET 762 treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 treatments altered DNA methylation-related genes in uLMS cells. RNA−seq revealed the downregulation of DNMT3A , DNMT3B , DNMT1 , TET1 , and TET2 in uLMS cells in response to JQ1 and I-BET 762 treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: DNA Methylation Assay, RNA Sequencing

    JQ1 and I-BET 762 altered the expression levels of histone modification-regulated genes in uLMS cells. RNA−seq revealed the altered expression of KDM1A , KDM1B , KDM4D , SETD6 , SETD9 , SETDB1 , SET , SETD9 , SIRT1 , and SIRT7 in uLMS cells in response to BETi treatments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 altered the expression levels of histone modification-regulated genes in uLMS cells. RNA−seq revealed the altered expression of KDM1A , KDM1B , KDM4D , SETD6 , SETD9 , SETDB1 , SET , SETD9 , SIRT1 , and SIRT7 in uLMS cells in response to BETi treatments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Expressing, Modification, RNA Sequencing

    JQ1 and I-BET 762 altered the expression levels of m 6 A regulators in uLMS cells. RNA−seq revealed the altered expression of FTO ( A ), IGF2BP1 ( B ), and YTHDC2 ( C ) in uLMS cells in response to BETi treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: JQ1 and I-BET 762 altered the expression levels of m 6 A regulators in uLMS cells. RNA−seq revealed the altered expression of FTO ( A ), IGF2BP1 ( B ), and YTHDC2 ( C ) in uLMS cells in response to BETi treatment. ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Expressing, RNA Sequencing

    Experimental model. Our experimental model shows that targeting BET proteins with JQ1 and I-BET 762 induces cell cycle arrest, modulates the Hedgehog and EMT pathways, and alters the TF network as well as interactions between target genes and epigenetic regulators in uLMS cells. This figure was created using the BioRender software online app ( BioRender.com ).

    Journal: Cells

    Article Title: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

    doi: 10.3390/cells13171443

    Figure Lengend Snippet: Experimental model. Our experimental model shows that targeting BET proteins with JQ1 and I-BET 762 induces cell cycle arrest, modulates the Hedgehog and EMT pathways, and alters the TF network as well as interactions between target genes and epigenetic regulators in uLMS cells. This figure was created using the BioRender software online app ( BioRender.com ).

    Article Snippet: The uterine leiomyosarcoma (uLMS) cell line (SK-UT-1, ATCC ® HTB-114 TM ) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

    Techniques: Software